Medical Research

Catalog

• #Case Control Study

  • #Design case-control study on e-cigarette use and lung injury. Help me: 1) Define cases (diagnostic criteria) and control selection, 2) Calculate required sample size (OR=2.5, 80% power), 3) Design data collection instrument (exposure assessment), 4) Plan statistical analysis (conditional logistic regression if matched), 5) Control for confounding (smoking history, demographics), 6) Calculate adjusted odds ratios with 95% CIs, 7) Consider recall bias and mitigation

• #Clinical Trial Protocol

  • #Write Phase II clinical trial protocol for new cancer immunotherapy. Help me: 1) Design study (randomized, double-blind, placebo-controlled), 2) Define eligibility criteria and recruitment strategy, 3) Detail intervention and control conditions, 4) Specify primary and secondary outcomes with measures, 5) Plan statistical analysis (sample size, interim analyses), 6) Address safety monitoring and adverse events, 7) Write informed consent document

• #Cohort Study Analysis

  • #Analyze prospective cohort data on diet and cardiovascular disease (10,000 participants, 15 years follow-up). Help me: 1) Calculate incidence rates by exposure groups, 2) Estimate relative risks and hazard ratios, 3) Adjust for confounders (age, sex, smoking, BMI) using Cox regression, 4) Test proportional hazards assumption, 5) Assess dose-response relationships, 6) Handle missing data appropriately, 7) Report per STROBE guidelines

• #Diagnostic Accuracy Study

  • #Analyze diagnostic accuracy of AI-based skin cancer detection vs dermatologists. Help me: 1) Calculate sensitivity and specificity with 95% CIs, 2) Create 2x2 contingency tables, 3) Generate ROC curves and calculate AUC, 4) Determine optimal cutoff using Youden index, 5) Calculate positive/negative predictive values, 6) Use STARD checklist for reporting, 7) Assess clinical utility for screening vs diagnosis

• #Meta Analysis Clinical

  • #Conduct meta-analysis of 20 RCTs on statin effectiveness for primary prevention. Help me: 1) Extract outcomes (mortality, cardiovascular events) from each trial, 2) Calculate pooled odds ratios and risk differences, 3) Assess heterogeneity (I², τ², Q test), 4) Perform sensitivity analyses, 5) Test for publication bias (funnel plot, Egger test, trim-and-fill), 6) Conduct subgroup analyses by patient characteristics, 7) Assess quality of evidence using GRADE

• #Systematic Review Protocol

  • #Design systematic review protocol on effectiveness of telemedicine for diabetes management. Help me: 1) Formulate PICO question (Population, Intervention, Comparison, Outcome), 2) Plan comprehensive search strategy (PubMed, Embase, Cochrane, CINAHL), 3) Define inclusion/exclusion criteria, 4) Select quality assessment tool (Cochrane ROB 2.0 for RCTs), 5) Plan data extraction and synthesis, 6) Register protocol on PROSPERO